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(2) Greenwood-Van Meerveld B, Tyler K, Mohammadi E, Pietra C

Since egr-1 is critical in proliferation, differentiation, and inflammation during cholestatic liver injury, cytokine and growth factor generation and early extracellular matrix (collagen) formation (Kim et al., 2006

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They have been shown to relieve nausea during pregnancy and chemotherapy

The FDA also recommends examining hard clinical endpoints such hepatic decompensations, transplant free survival, and all-cause mortality, although these results are not necessarily needed prior to drug approval given the long length of follow up potentially required