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Additionally, metformin may influence lipid metabolism, smooth muscle contractions of the vascular system, hypercoagulation, platelet hyperactivity, calcium handling within cardiomyocytes and endothelial cell function [34]
It counteracts muscle atrophy and promotes full functional recovery, as evidenced by improved biomechanical and functional assessments in treated rats
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In the landmark STEP 1 clinical trial, participants taking Wegovy alongside a reduced-calorie diet and increased physical activity lost an average of 15% of their body weight over 68 weeks
