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In REDEFINE 1 (overweight/obesity without T2D), CagriSema achieved mean weight reductions of 20.4-22.7% (vs 2.3-3.0% placebo) at 68 weeks, with 53.6% and 34.7% of patients achieving 20% and 25% weight loss, respectively
(These probiotics are known as commensal strains naturally found in the human gut
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A key driver of this process is insulin resistance, which affects both hepatic and peripheral tissues, creating a metabolic environment that simultaneously promotes hyperglycemia and hepatic steatosis through selective pathway activation
There are no published guidelines regarding the optimal management of pasireotide-induced hyperglycemia based on its pathophysiology
