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In contrast, stimulant medications typically cause side effects related to sympathetic nervous system activation

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Pathophysiology of GLP-1 therapy induced nausea and vomiting GLP-1 receptor agonists cause nausea and vomiting mainly by binding GLP-1 receptors in the dorsal vagal complex (DVC), a specific vomiting and nausea control center in the brainstem

GLP-1Rs are expressed on eosinophils and neutrophils, and GLP-1RAs can attenuate eosinophil activation and LPS-induced expression of pro-inflammatory cytokines, including IL-1, IL-1, IL-6, TNF- and IFN- (23,149,150)