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In line with alterations of the small intestinal microbiota mediating nutrient-induced gutbrain signaling, direct small intestinal infusion of Lactobacillus gasseri restores intestinal lipid sensing 49,130

GLP-1 is a 30-amino acid peptide hormone produced by differential post-translational processing of the proglucagon precursor protein by prohormone convertase 1/3 (PCSK1) in intestinal L-cells and in neurons of the nucleus tractus solitarii (NTS) in the brainstem

In this context, nutritional management becomes not merely supportive but an integral component of maintaining metabolic stability during pharmacological weight reduction

Practitioners should note that they only work when combined with a healthy lifestyle that promotes weight loss

Endocrine 50 , 620626 (2015)