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The first GLP-1 drug, Exenatide (brand name Byetta), was approved by the Food and Drug Administration in 2005 to treat type 2 diabetes

12 Therapeutic GLP-1 receptor agonism has been associated with delayed gastric emptying, which aids in weight loss by reducing appetite, increasing satiety, and reducing energy intake

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This variability is influenced by differences in the permeability of the bloodbrain barrier (BBB) and the bloodcerebrospinal fluid (CSF) barrier, as well as by region-specific expression of enzymes involved in glutathione metabolism