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Topical Medications & Products: Prescription creams or advanced cosmeceuticals work to inhibit melanin production and lighten existing pigmentation

That distinction matters for sourcing, see our best compounded tirzepatide pharmacies guide for which providers still dispense legally in 2026

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The variability found in our results is also consistent with RCT results demonstrating a continuum of effects - while overall ETD for weight loss was attenuated in our study, the RCTs for semaglutide and tirzepatide have also shown that between 9-14% of patients lost less than 5% of body weight over 12 months, and between 16-33% lost less than 10%