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2023 Apr 30;16(5):676

The 0.5 mg/mL inclusion is well below any clinical toxicity threshold and has no effect on tirzepatide's GIP or GLP-1 receptor binding

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A peer-reviewed study in the Journal of Endocrinology confirming that AOD9604 produces lipolysis and increases fat oxidation in obese mice via the beta-adrenergic pathway, with effects comparable to full-length HGH but without the insulin-disrupting side effects provided early mechanistic validation that informed the human trials