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After reviewing 21 clinical trials, researchers concluded that vitamin B supplements may delay cognitive impairment associated with aging
Long-term human data beyond 6 months remains limited, but preclinical toxicology studies in animals showed no concerning findings with chronic administration
Neurological symptoms are particularly significant and may include: Paraesthesia (pins and needles) in the hands and feet Numbness or altered sensation in the extremities Difficulty walking or problems with balance and coordination (ataxia) Memory problems and cognitive difficulties Mood changes, including depression and irritability Visual disturbances in severe cases Haematological and general symptoms commonly include: Pale or jaundiced (slightly yellow) skin Glossitis (sore, red, smooth tongue) Mouth ulcers and angular cheilitis (cracks at the corners of the mouth) Breathlessness, particularly on exertion Heart palpitations Headaches and dizziness Gastrointestinal symptoms may present as: Loss of appetite and unintentional weight loss Diarrhoea or constipation General digestive discomfort The severity and combination of symptoms vary considerably between individuals
Read safety information Supporting research A selection of peer-reviewed work on AOD 9604/MOTS-C
Healthcare providers use guidelines to decide the right dose and how often to give it
