Certain factors may put you at increased risk for B12 deficiencyincluding a vegetarian or vegan diet, specific medical conditions (such as Crohns or celiac disease, or a history of gastric surgery), and age over 50
If you have a high-stress life, high caffeine intake, or high alcohol intake, you may need extra B12
It remains an investigational peptide used in clinical and research settings outside of formal FDA-approved indications
Neurologic manifestations will not be prevented with folic acid, and if not treated with vitamin B12, irreversible damage will result
For patients with fatigue alongside body composition concerns, this combination is conceptually compelling, though formal research on the combination is limited