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The dividing line is absorption, not severity

[5] Nevertheless, any signs of hypersensitivity (such as a diffuse rash, wheezing, or feeling of throat tightness) warrant stopping the injection and seeking prompt medical care

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Its job is specific: it inhibits an enzyme called NNMT nicotinamide N-methyltransferase that becomes overactive in fat tissue, especially as we age

Sublingual and transdermal formulations have shown negligible absorption in bioavailability studies, making injection the only viable route for these compounds