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Research on rapid weight loss, whether from dieting or from GLP-1 medications, shows that when protein and exercise are neglected, a meaningful share of the weight lost can come from muscle rather than fat
It also blocks the glucagon secretion
Then, glutamate can be converted to -KG by GDH
Real-World Adherence Collapse Clinical trials set a high bar for GLP-1 effectiveness , but they do so in highly controlled conditions with selective populations
2025 Nov;16(11):2237-56
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