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Hyperglycemia Diabetes is associated with the accelerated disappearance of capillary endothelium [159], morphological and functional alterations of ECs [160], and the weakening of intercellular junctions [161], which ultimately leads to ECD

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The first chemical event is peptide bond hydrolysis at the most thermally vulnerable linkage, typically between histidine and phenylalanine residues in the Melanotan-2 sequence