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Efficacy is unaffected once the peptide reaches the bloodstream it sits in the bodys own roughly 150 mM saline regardless of what you mixed it with. NAD+ is different: its pain is acidity, not mast cells reconstituted NAD+ sits near pH 3.5

To that end, there are reputable clinics in the United States that prescribe KPV and other restricted peptides, though they are still few and far between

Room temperature BAC water is perfectly fine for reconstitution

It solved the problem I had with reagent degradation, allowing for more consistent results across my experiments