This is accompanied by podocyte injury, characterized by podocyte hypertrophy, foot process effacement and detachment of podocytes from the glomerular basement membrane
Laakso M, Zilinskaite J, Hansen T, Boesgaard TW, Vanttinen M, Stancakova A, et al
This is partly due to the ABCG2 efflux pump, which transports sulfasalazine out of cells, reducing its absorption and effectiveness [205]
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