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Unlike stimulant medications such as amphetamines or methylphenidate, tirzepatide does not act on the central nervous system's dopaminergic or noradrenergic pathways to increase alertness or blood pressure

10.1161/ATVBAHA.113.301586

When estrogen declines, each of these systems is affected

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(Boachie J, et al., Nutrients, 2020 PubMed: 32630646 ) Inositol and metabolic benefit A 2024 meta-analysis in the Journal of Clinical Endocrinology and Metabolism found inositol produced selective metabolic benefits in women with PCOS primarily as oral supplementation, not injected MIC formulas