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Long-term human safety has not been established, and telomerase activity is relevant to malignant-cell survival
Some preliminary research also suggests potential benefits for cartilage and joint health, though this application requires further clinical investigation
If needed for a clear medical indication (such as treating pellagra in a pregnant patient), niacinamide can be used with caution, but unnecessary high-dose B supplementation is avoided in pregnancy
Cold exposure has been practiced for centuries without identified chronic harms in otherwise healthy individuals
The peptide also stimulates superoxide dismutase production, providing antioxidant protection against free radical damage
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