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This study found that semaglutide significantly upregulated the levels of Ppar and downstream genes Cpt-1a , Pgc1 , and Hsl in adipose tissue, and Ppar , Cpt-1a , Pgc1 in the liver

Central nervous system changes revert, diminishing satiety signals.[10][12][1] Hormonal shifts include rising ghrelin and falling peptide YY, fueling rebound

This can be very painful and usually needs medical care right away

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For otherwise healthy adults, results are less predictable and often modest