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Estrogen decline, insulin resistance, and midlife weight gain in menopause The transition to menopause is associated with a decline in estrogen, demonstrating an important link between hormonal changes, insulin resistance, and the common experience of midlife weight gain, particularly around the abdomen

Discussion Our concept, which we verified in several previous paper [24, 32, 33, 42], is that if we mimic the specific expression pattern of nutrient transporters at the BBB with a combination of two or three different ligands a more specific targeting of nanoparticles across the BBB can be achieved

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This evidence raises the potential of GLP-1R agonists for treating both rare and more common neurological diseases with a strong mitochondrial component e.g

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