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It engages the ghrelin/GHS receptor to stimulate pulsatile GH release with high specificity, without significantly elevating ACTH, cortisol, or prolactin

GLP-1 receptor agonists like semaglutide (Wegovy) and liraglutide (Saxenda), along with tirzepatide (Zepbound), are FDA-approved medications for chronic weight management that work by regulating appetite and metabolism

This comprehensive review synthesizes pharmacological evidence across disease indications, evaluates bioavailability enhancement strategies, explicitly discusses evidence limitations, addresses safety considerations, and outlines translational research priorities essential for clinical or nutraceutical development