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In a randomized, double-blind, placebo-controlled trial, daily supplementation with Lactobacillus plantarum ECGC 13110402 for 12 weeks in adults with moderate hypercholesterolemia resulted in a significant reduction in LDL cholesterol and hs-CRP compared to placebo, suggesting a direct benefit of probiotics on cardiovascular risk markers in humans (Costabile et al., 2017)

Yin L, Mano J, Wang S, Tsuji W, Tanaka K

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Beyond direct actin binding, TB-500 engages integrin-linked kinase (ILK) and AKT signalling pathways, extending its activity into cell-survival and migration signalling