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Persistent increase in oxygen consumption and impaired neurovascular coupling after spreading depression in rat neocortex

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According to ADA guidelines, these medications are preferred second-line agents for patients with established atherosclerotic cardiovascular disease

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The real appeal of metformin as a tirzepatide alternative lies in its cost (as low as $4-10 per month for generic), its extensive safety record spanning decades, and emerging research suggesting longevity benefits independent of blood sugar control