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In Capsoni et al.'s study, intranasal administration of human nerve growth factor painless (hNGFp) was performed in Ts65Dn mice at an early stage, before the accumulation of amyloid precursor protein (APP) leading to neurodegeneration

These molecules can be derived from natural sources, including food, venoms, and marine organisms [16, 17], or synthesized through enzymatic hydrolysis and recombinant DNA technologies [18]