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The 15mg dose in SURMOUNT-1 produced the 22.5% average body weight reduction, but this was measured at week 72, so the full effect takes time
Similarly, a post-hoc analysis of SURPASS-1, enrolling 478 patients with T2D, found that all doses of tirzepatide as monotherapy increased insulin sensitivity compared to placebo, as suggested by the decreases in HOMA2-IR by 923% (vs +14.7% with placebo) and fasting insulin levels by 212% (vs +15%) and the increase in adiponectin by 1623% (vs 0.2%) and IGFBP-2 by 3870% (vs +4.1%) at 40 weeks [76]
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discussion 287 Capps DH, Brodsky MC, Rice CD, Mrak RE, Glasier CM, Brown HH
While it may start to lower blood sugar and reduce appetite within hours, significant weight loss typically occurs over several weeks or months
