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This leads to the release and cytoplasmic translocation of p53, which can subsequently activate transcription-independent pro-apoptotic signaling (Figures 6A,B)
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Post-translational modifications, especially those in the DNA binding domain of FOXO4 protein, appear to modify its functionality as a transcription factor and regulation of pathways such as apoptosis, cellular senescence, insulin signaling, and senescence
Liu J, Shen JX, Wen XF, Guo YX, Zhang GJ
In my attempt to be brave, I tried to tell myself these, hopefully, rarely ever happen, signed the waiver, and crossed my fingers that things would go smoothly...and thankfully they did
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