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Nevertheless, GIP receptor antagonism is thought to exert beneficial metabolic effects due to the expression of GIP receptors on adipocytes (94), along with elevated circulating GIP levels observed in both individuals with obesity (95) and individuals given a high-fat-diet (96)
Among those who have used GLP-1 drugs, about half report they have experienced nausea and about one-third experienced diarrhea
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In addition, expanding clinical evidence supporting cardiovascular and renal benefits is encouraging broader prescribing across patient populations
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