It is the rare drug (some types of tetracycline) that become toxic if outdated
Cell Metab 31(2):339350 Lignitto L, LeBoeuf SE, Homer H, Jiang S, Askenazi M, Karakousi TR, Pass HI, Bhutkar AJ, Tsirigos A, Ueberheide B, Sayin VI, Papagiannakopoulos T, Pagano M (2019) Nrf2 activation promotes lung cancer metastasis by inhibiting the degradation of Bach1
Another preclinical study using presymptomatic and symptomatic SOD1 G93A transgenic mice revealed an association between the accumulation of ceramides and cholesterol esters in the spinal cords of ALS patients and OS, thus highlighting the pivotal role of OS in inducing an alteration in the metabolism of sphingolipids metabolism which mediates MN death in ALS [112]
However, the exact mechanisms and timing underlying BBB disruption and its role in the onset and progression of disease are not yet fully understood (Nian et al., 2020)
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