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There is currently no effective targeted therapy to treat MPNSTs and surgical removal remains the mainstay treatment

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Collectively, these findings provide a mechanistic rationale for developing multi-target agonists: GLP-1R appears to provide the most potent and direct anti-MASLD and anti-fibrotic effects in the liver, while GIPR and GCGR offer complementary benefits for glucose and lipid metabolism, with GIPR also exhibiting superior cardiovascular protection