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Activated ASK1 phosphorylates c-Jun N-terminal kinase (JNK) via cytosolic mitogen-activated protein kinase 4/7

Safety and tolerability outcomes comprised discontinuation of treatment due to adverse events, incidence of serious adverse events, all-cause mortality, hypoglycaemia (plasma glucose 3.9 mmol/l), severe hypoglycaemia (a hypoglycaemic event requiring assistance), nausea, vomiting and diarrhoea

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FOXO4-DRI disrupts this interaction, freeing p53 to initiate targeted apoptosis specifically in senescent cells