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Main clinical impact of these technologies is an early identification of subclinical neuropathy that allows prompt implementation of intensive glycemic control, lifestyle interventions and neuroprotective therapies, which in turn has been shown to slow DPN progression and reduce incidence of foot ulcers and falls

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For example, selonsertib (GS-4997) is a highly selective and potent ASK1 inhibitor with potential anti-inflammatory, anti-tumour, and anti-fibrotic activities 40

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