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The selectivity claim is well-grounded mechanistically and in animal models, but it should be labeled as such rather than stated as a confirmed human clinical fact

Different approaches in the management of CKD associated with T2D Historically, a linear approach to pharmacologic management has been used, in which drugs are added then adjusted, optimized, or stopped in a stepwise manner based on their efficacy, toxicity, effects on a patients quality of life, and cost [39]

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