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4.3.3 Iron homeostasis disruption Cigarette smoke (CS) perturbs systemic and cellular iron homeostasis through several interconnected mechanisms: (1) Hepcidin Upregulation: CS exposure elevates hepcidin expression, which subsequently downregulates the iron exporter ferroportin (FPN)

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doi: 10.7759/cureus.88216 Summary Keywords GLP-1 receptor agonists, insulin resistance, metformin, myoinositol, network meta-analysis, obesity, polycystic ovary syndrome Citation Omarion A, Ayasa Y, Omarion Z, Jayouse B and Ayesh H (2026) Comparative analysis of glucagon-like peptide-1 receptor agonists, metformin, and inositol in improving anthropometric and metabolic outcomes in women with polycystic ovary syndrome: a network meta-analysis

This peptide works by promoting lipolysis, the process of breaking down fats into fatty acids, which are then utilized for energy production