Masse, KE, Lu, VB Short-chain fatty acids, secondary bile acids and indoles: gut microbial metabolites with effects on enteroendocrine cell function and their potential as therapies for metabolic disease
Practical Application Omega-3 rich fish: Salmon, mackerel, sardines, anchovies Monounsaturated fats: Extra virgin olive oil, avocados, almonds Plant-based omega-3s: Flaxseeds, chia seeds, walnuts Medium-chain triglycerides: Coconut oil (moderate amounts) Include healthy fats in each meal (10-15 grams per meal) Pair fats with protein and fiber for sustained L-cell activation Avoid excessive saturated fat which may impair L-cell function Strategy 5: Meal Composition and Sequencing The Science: L-cells dont just respond to individual nutrientsthey respond to the pattern, sequence, and combination in which nutrients arrive
The texture also skewed thick and slightly gritty, which worked better with richer flavors than fruit-forward ones
Advanced users or those with higher body weight may use up to 100mg daily, either as a single dose or split into two 50mg doses taken 12 hours apart
( A and B ) Intracellular cAMP accumulation measured by enzymatic immunoassay in lysates from ( A ) caSMCs and ( B ) mouse and human caECs treated for 10 minutes with 100 nM each of GLP-1(2836), scrambled control, IPE, forskolin, or PBS control ( n = 3/treatment, each in triplicate)