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Muscle Composition and Quality Myosteatosis, characterized by abnormal fat infiltration in skeletal muscle (muscle fat infiltration, MFI) encompassing both intermuscular and intramyocellular fat, negatively affects muscle capacity and quality, leading to functional impairment and increased metabolic and physical health risks [79]

The possible role of phentermine has not been established, therefore the possibility of an association between heart valve disease and the use of phentermine alone cannot be ruled out

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Nevertheless, further preclinical and clinical investigations are warranted to validate these results and explore their translational relevance in human diabetic populations

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