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There are simply too many signals at work in our bodies to ensure full calorie storage At the same time, we observed that key hormones regulating body weight, like the satiety hormone leptin and the hunger hormone ghrelin, were acting in the brain to achieve their effects
But "most effective" is not always the same as "best for you." Several considerations: Tolerability matters
Kober and Brett, 2017
Mol Neurobiol 62:36533672
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