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Medical necessity is also a frequent trigger

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- People with significant liver disease (the 9-month monkey toxicology study showed dose-dependent periportal vacuolation in hepatocytes that the FDA flagged as a possible safety signal)

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However, there are significant precautions and concerns regarding its use, particularly related to tumor growth and the lack of rigorous human studies

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PMCID: PMC7714782

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Komagata D et al

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