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Semaglutide, the active ingredient in Ozempic, Wegovy, and Rybelsus, is a glucagon-like peptide-1 (GLP-1) receptor agonist

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The firm side, on the other hand, feels more lifted: It feels more like youre lying on top of the mattress rather than sinking into it, which makes it easy to move around on and change positions," says our long-term tester