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Research indicates that even modest weight reduction of 5-10% of body weight can significantly improve reproductive hormone profiles, including reductions in insulin resistance, androgens, and improvements in sex hormone-binding globulin levels

Cost is one of the biggest reasons people cannot stay on these drugs long term, even when they work well and improve quality of life

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Most patients commit to a 4-8 week protocol cycle, depending on the recovery concern

372 In vitro, GLP-1 disrupts the ability of osteoblasts to survive and differentiate by triggering the activation of c-Fos, which is a proto-oncogene