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Meanwhile, CagriSema was associated with increased rates of GI adverse effects and mild hypoglycemia

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When produced excessively, it may suppress the release of Thyroid Stimulating Hormone from the pituitary. 18 It also forces T4 to be converted to reverse T3 (rT3) which actually blocks thyroid function, even though thyroxine levels look adequate when tested. 19 Blood glucose imbalance also triggers cortisol secretion, and insulin resistance may have a direct negative effect on the thyroid, too

Andersen G, Wegner L, Jensen DP, Glmer C, Tarnow L, Drivsholm T, et al

Weight loss achieved before pregnancy often provides metabolic benefits that persist even after the medication is stopped