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In practice, clinics adapt trial titration schedules by starting most patients at 1 mg once weekly for 24 weeks, which is considered the safest entry point for minimizing GI side effects
Treatment of animals Four groups of Sprague-Dawley rats housed under the same conditions and fed on the same diet were used in this experiment
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Genetics and individual metabolism There is emerging evidence that genetic variations in GLP-1 receptor expression and sensitivity affect both the therapeutic response to semaglutide and the side effect profile
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