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A high-throughput screening of synthetic compounds aimed at identifying substances capable of eliminating tumor cells led to the discovery of erastin, a compound exhibiting RAS-selective activity ( Table 2 )
We cover mechanism overlap, current evidence quality, dosing frameworks, and the gaps practitioners need to know before combining these two compounds
Moreover, insulin-like growth factor binding protein related proteins (IGFB- PrPs) have been recently characterized, which aid the metabolic effects of the hormone but their role remains unclear [8]
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