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Common Side Effects: Nausea and Vomiting : Frequently occurs when starting semaglutide or increasing the dose Diarrhea: Common during the initial phase of treatment Constipation : Affects some patients during treatment Abdominal Pain : This may occur, often mild to moderate Headache : This can occur, especially at the start of treatment Fatigue : Ensure sufficient rest and a balanced diet

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19,67,73,74 Newly proliferated reactive astrocytes form borders that separate damaged, inflamed, and fibrotic tissue from adjacent viable neural tissue, and during this border formation newly proliferated astrocytes become transcriptionally reprogrammed to adopt new cellular interactions with non-neural cells

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