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Reported changes tend to be gradual and cumulative rather than immediate

Type 1 diabetes patients do not have amylin treatment and, therefore, have unphysiological postprandial glucagon secretion, fast gastric emptying, and impaired satiety signaling, all of which are factors that can contribute to glycemic variability, postprandial hyperglycemia, and weight gain in intensive insulin therapy

This region has particularly poor blood supply, contributing to its susceptibility to overuse injury and its slow natural healing

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