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GLP-1 also promotes neurogenesis by stimulating neurotrophic factors as GDNF, VEGF, and BDNF and reduces inflammation by decreasing TNF-a, IL-6, IL-10, and microglial activation (Erbil et al., In addition to its role in neuroprotection, current evidence showed that GLP-1 affects reward pathways

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The Wnt/-catenin/RAS axis is also implicated in DOXO-induced cardiomyopathy, with TNF- acting as an upstream stimulator.Inhibition of TNF- using infliximab or rolipram has shown protective effects against DOXO-induced cardiomyopathy in animal models

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