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Tirzepatide offers very high efficacy for weight loss (more than semaglutide, based on recent evidence) most likely due to its dual mechanism, while semaglutide has established itself as a leader with its proven cardiovascular benefits, said Jennifer Clements, PharmD, BCACP, BC-ADM, BCPS, CDCES, FADCES, FCCP
However, C4 was more strongly associated with breast cancer among individuals with a luminal B-like (HER2-positive or negative) subtype than other surrogate subtypes
The relationship between GLP-1 medications and each may also be very different
Injectable tirzepatide produces approximately 20.2% weight loss at 72 weeks (at maximum dose in the SURMOUNT-5 trial)
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