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2 mg Weeks 14 Introductory dose to establish tolerability

In clinical trials, retatrutide produced 24.2% weight loss at 48 weeks compared to tirzepatide's 20.9% at 72 weeks

Their mechanism of action involves several complementary pathways: Enhancing glucose-dependent insulin secretion from pancreatic beta cells, which helps lower blood glucose levels when they are elevated Suppressing glucagon release from pancreatic alpha cells, reducing hepatic glucose production Slowing gastric emptying , which moderates the rate at which nutrients enter the bloodstream Promoting satiety through central nervous system effects, leading to reduced appetite and caloric intake These combined effects result in improved glycaemic control in people with type 2 diabetes and significant weight loss in those using higher doses for obesity management

1,2,6 Symptoms typically include being easily fatigued with exertion, palpitations, and skin pallor

Draganov et al