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Papaya Extract: Papaya contains papain, an enzyme that exfoliates the skin and helps fade dark spots

It provides vitamin B12 and selenium for treatment and control of deficiency

That means: Hypokalemia can develop or worsen which can lead to: Cardiac arrhythmias Muscle weakness QT prolongation In severe cases, sudden cardiovascular instability This is a classic board-style pearl that many clinicians forget because B12 feels benign. But in profoundly deficient patientsespecially those with severe megaloblastic anemiarepletion is metabolically active treatment

This study of more than 16,400 subjects found a 27% increased rate of hospitalization for acute HF after approximately 2 years of saxagliptin therapy ( P = .007)

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