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Meanwhile, the most frequently reported adverse effects of GLP-1 RAs are gastrointestinal, including nausea, vomiting, and diarrhea ( In previous real-world studies of GLP-1 RAs-induced hypoglycemia, lixisenatide showed the strongest association (Zhao et al., 2021), consistent with our finding (Figure 2)
However, it's unclear what kind of optic nerve disorders this includes, as the medical record codes used didn't specify
For a broader overview of this class and the kinds of effects people commonly notice, our GLP-1 side effects overview can help put the sleep conversation into context
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NICE guidance requires at least 5% weight loss after 6 months at maintenance dose for treatment continuation, with maximum recommended duration of 2 years
