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Type 2 diabetes is a chronic, progressive condition, and most people require ongoing medication to maintain glycaemic control

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It is involved in preadipocyte differentiation via PPARG activation, suggesting a potential mechanism by which estrogen contributes to adipocyte hyperproliferation and fat accumulation in lipedema.7 Also, adipocytes in lipedema may exhibit enhanced local production of steroidogenic enzymes, further increasing local estrogen activity through ER activation and perpetuating adipose tissue expansion.15 Recent multi-omics studies have identified metabolic, lipid, and gene expression abnormalities in lipedema

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The energy expenditure effects contribute to Retatrutide's superior weight loss efficacy compared to GLP-1-only therapies

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The STEP 1 trial showed an average weight loss of 14.9% of body weight at this dose over 68 weeks

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Moisturise well and apply sunscreen daily

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