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The American College of Gastroenterology (ACG) emphasizes that hematochezia should always be investigated because it may be the presenting symptom of serious colorectal pathology

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No secondary cause is identified after evaluation

Slowly increasing the dose of a GLP-1 medication allows the body time to adjust to the changes that are occurring, especially the slowing of gastric motility, says Currier, So the key to avoiding the nausea as much as possible is to take the titration phase slowly and allow the body time to acclimate appropriately. If someone increases the dose too quickly or overdoses, theyre more likely to experience severe nausea

(A) Overview of experimental procedure